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Association of spironolactone use with risk of urinary tract cancer in the general population: A matched population-based cohort study.

PLoS One · 2024 · PMC10971784 · PMID 38536840

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a decreasing trendno p-value reported
an increasing trendno p-value reported
Overall, whether the change in aHR assessed in terms of cumulative dose or duration of exposure to spironolactone, we observed a decreasing trend in prostate cancer risk and an increasing trend in renal cancer risk.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.