Vitamin D₃ deficiency and osteopenia in spastic paraplegia type 5 indicate impaired bone homeostasis.

In line with the decrease in sclerostin levels, BAP serum levels showed an increasing trend in the verum group (12.0 ± 2.4 μg/l) compared to the placebo group (10.8 ± 2.6 μg/l; p = 0.789) but did not reach levels of matched controls (16.9 ± 1.5 μg/l—Fig. 3 E).

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