The Validation and Determination of Empagliflozin Concentration in the Presence of Grapefruit Juice Using HPLC for Pharmacokinetic Applications.

The T max in Group C was increased in comparison to Group B, to become 2 h, the C max and AUC in Group C were equal to 2936 ng/mL and 18,657 ng × h/mL, indicating that there is a highly significant increase in the C max plasma and AUC as compared statistically, and as shown in Figure 4 and Figure 5 . 3.

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