Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies.

Most of these lipids show an increasing trend throughout rats’ lifespan starting in 6-months with a gradual increase in 8–10-month-old animals and older (Fig. 3 C).

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Quantification revealed NeuN-positive neuronal cells with a decreasing trend of GLUT3 staining in 6-month-old animals, and significant decrease of GLUT3 in 8-, and 10-month-old animals (Fig. 8 A-D, 8-month-old animals: CN: 25.07 ± 1.43, Tg: 20.91 ± 0.54; p = 0.035; 10-month-old animals: CN: 28.37 ± 1.03, Tg: 22.36 ± 1.67; p = 0.022).

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