Although this subpopulation represents only 11%–13.5% of VitA + and 5%–7% of VitA − Col1a1 -expressing cells, due to its 4–12-fold-higher expression of the profibrotic and MFB genes, the potential contribution of this subset to fibrogenesis in AH may be significant.
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Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis.
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