Diaryldiazoketones as Effective Carbene Sources for Highly Selective Rh(II)-Catalyzed Intermolecular C-H Functionalization.

The reaction with trans -2-hexene ( 8 ) is also highly significant because it is used to determine primary versus secondary site selectivity, and the reaction with a bulky catalyst favors that the primary C–H insertion products have been used as a key step in a total synthesis. 9 Rh 2 ( S -TPPTTL) 4 is not a bulky catalyst. 7 Hence, the preferred site selectivity is at the secondary site, although the reaction proceeds to form 10 with poor diastereoselectivity and enantioselectivity.

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