A diagnostic phase III/IV seamless design to investigate the diagnostic accuracy and clinical effectiveness using the example of HEDOS and HEDOS II.

Stat Methods Med Res · 2024 · PMC10981198 · PMID 38327081

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a slight trendno p-value reported

40 did a literature review on adaptive designs in clinical trials and highlighted a slight trend on the reception of adaptive designs by regulatory agencies in the USA and Europe of adaptive designs.

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