Isoquercitrin alleviates pirarubicin-induced cardiotoxicity <i>in vivo</i> and <i>in vitro</i> by inhibiting apoptosis through Phlpp1/AKT/Bcl-2 signaling pathway.

Front Pharmacol · 2024 · PMC10982373 · PMID 38562460

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highly significantno p-value reported

Differences were statistically significant at p < 0.05 and highly significant at p < 0.01. 3 Results 3.1 Effects of IQC on THP-induced cardiotoxicity hemodynamics and electrocardiograph Compared to the CON group, the THP group had substantially reduced LVSP and ±dp/dtmax values, but significantly higher LVEDP values.

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