SUMO modifies GβL and mediates mTOR signaling.

Note, the ∼30% decrease in the interaction is highly significant ( Fig. 6 , A and B ) as SUMO1/2/3Δ cells show only ∼40% depletion of SUMO, compared with control cells ( Fig. 5 B ), indicating that SUMO selectively and strongly regulates the interaction of mTOR with Raptor and Rictor.

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