Moreover, we found highly significant hypermethylation in subfamilies of endogenous retroviruses, including active elements ( Fig. 5 I; Kozak 2015 ; Fu et al. 2019 ).
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A maternal-effect <i>Padi6</i> variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos.
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