Individuals with Alzheimer's disease and low tau burden: Characteristics and implications.

The tau × α‐synuclein interaction was significant in 5/6 models, and marginally significant in the remaining model, such that α‐synuclein+ status was associated with poorer PACC and MMSE scores only when tau (across all three regions of interest) was low (Table 2 , Figure 3 ). 3.4 Tau regional rankings We examined the ranked regional distributions of tau in 70 FreeSurfer‐defined regions for each individual, then determined the median rank of each region for unimpaired and impaired A+T− and A+T+ groups.

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