Neuropathology of patients with preclinical or early clinical Alzheimer's disease with pathogenic PSEN1_p. L392V: Comparison of advanced siblings.

Additional clinicopathological investigation for familial AD‐related mutation carriers may be significant to explore the association between familial AD and suicide. amyloid‐β autopsy familial Alzheimer's disease immunohistochemistry neurofibrillary tangle presenilin 1 suicide JSPS KAKENHI JP21H03211 to YH JP23H03759 to NN Microscopically, in Case 1, the abundant amyloid plaque, including the neuritic plaque, was noted in the whole brain.

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