Greater white matter degeneration and lower structural connectivity in non-amnestic vs. amnestic Alzheimer's disease.

In tests of global cognition, a highly significant group effect ( Table 2 ) reflected significantly better cognition for the CN group than all patients (all T > 4.1, p < 0.0001); no significant differences were found between phenotypes (all T < 1.72, p > 0.08).

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Associations between Betti metrics and disease duration also remained significant and highly consistent; the only exception was that the association between disease duration and Betti-0 number in the full analysis ( p = 0.0241) became marginally significant in the subset analysis ( p = 0.0665).

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