When the histone acetylome was initially examined through MS mapping, the hyperacetylated form of histone H4 peptide H4K5K8K12K16-3ac showed a decreasing trend in all acetyltransferase-depleted cells, while the levels of the other acetylated peptides remained relatively unchanged (Figs. 3A and EV3A ).
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Hyperacetylated histone H4 is a source of carbon contributing to lipid synthesis.
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