Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice.

2.5 Identification of the common gene Disease-associated microglia (DAM) genes were obtained from Keren-Shaul et al.‘s research ( Keren-Shaul et al., 2017 ), including APOE , CST7 , LPl , SPP1 , ITAGX , CLEC7A , CSF1 , IGF1 , AX1 , ANK , TYROBP , CD63 , CTSD , CTSB , TREM2 , CTS1 , CD9 , CTSZ , CCL6 , P2RY12 and TMEM119 , which are highly significant genes related to DAM.

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The neuropathology observed in late onset AD (LOAD) is essentially identical to that observed in EOAD ( Walsh and Selkoe, 2004 ), although there may be significant differences between EOAD and LOAD.

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