A novel strategy for D-psicose and lipase co-production using a co-culture system of engineered Bacillus subtilis and Escherichia coli and bioprocess analysis using metabolomics.

Bioresour Bioprocess · 2021 · PMC10992840 · PMID 38650263

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a decreasing trendno p-value reported

However, none of them showed a decreasing trend, which was different from the accumulation of metabolic by-products of B. subtilis .

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an increasing trendno p-value reported

In the co-culture system, the production of D-psicose increased steadily towards the maximum concentration of 11.70 g/L, and the lipase activity showed an increasing trend to a maximum of 16.03 U/mg.

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