Panax notoginseng saponins prevent dementia and oxidative stress in brains of SAMP8 mice by enhancing mitophagy.

The abundance of NDP52 protein decreased significantly in model mice compared with that in the controls ( P < 0.01), and the level of OPTN protein exhibited a decreasing trend ( P > 0.05); however, treatment with high- and low-dose PNS induced a significant elevation in the levels of NDP52 and OPTN proteins ( P < 0.05) (Fig. 4 E-I).

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Hippocampal microtubule–associated protein 1 light chain 3 (LC3) and sequestosome 1 (P62) mRNA showed an increasing trend in model mice, and the trend was reversed in mice treated with high-dose PNS.

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