Randomized Controlled Trial of the Effect of an Exercise Rehabilitation Program on Symptom Burden in Maintenance Hemodialysis: A Clinical Research Protocol.

A 7-point change in severity score is likely to be clinically significant because this magnitude of change (1) is consistent with the resolution of 1 “very bothersome” symptom plus a 1-point change in severity of 2 symptoms and likely to be significant to patients (where “very bothersome” symptom equals 5 points), and (2) is approximately 1 SE of the mean based on our pilot data (SD 30, n = 18) and consistent with distribution-based methods.

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