New retinoblastoma (RB) drug delivery approaches: anti-tumor effect of atrial natriuretic peptide (ANP)-conjugated hyaluronic-acid-coated gold nanoparticles for intraocular treatment of chemoresistant RB.

7B , the injection regimen of ANP‐HA‐GNPs in treatment setting II did not significantly reduce RB tumor growth in comparison to the controls, whereas topical administration of ANP‐HA‐GNPs eye drops led to a significant tumor reduction after the first treatment cycle at Day 17 and further, not yet significant, reduced tumor growth upon Day 24 (Fig. 7C ).

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