Transcriptome-wide analysis of the function of Ded1 in translation preinitiation complex assembly in a reconstituted in vitro system.

Importantly, 87% of mRNAs showing significant increases in mRPFs at 100 nM Ded1 were also increased at 500 nM Ded1 ( Figure 2D ), and 68% of the mRNAs with significantly diminished mRPFs at 100 nM Ded1 were also decreased at 500 nM Ded1 ( Figure 2E )—both highly significant overlaps.

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