Leptin signalling regulates transcriptional differences in granulosa cells from genetically obese mice but not the activation of NLRP3 inflammasome.

With regard to the ob model, GO analysis of downregulated genes revealed highly significant terms such as “collagen-containing extracellular matrix”, comprising the genes Col4a2 and Col16a1 (Supplementary Fig. 1 C), which are important components of the ECM necessary for follicular development and ovulation 66 .

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