Rapid altitude displacement induce zebrafish appearing acute high altitude illness symptoms.

In tests performed on the head after the construction of the zebrafish AHAI model after 2 h at 6000 m (HA 2h) groups and after 5 h at 6000 m (HA 5h) groups respectively, we found a highly significant increase in the levels of ROS ( Fig. 4 A and B) and MDA ( Fig. 5 , B) in the HA 2h group compared to the control group, as well as a significant decrease in the levels of SOD, CAT, and GSH ( Fig. 5A– C, and D), which was attributed to the fact that low-pressure hypoxia decreases the activity of the antioxidant enzyme system, thus leading to oxidative stress [ [38] , [39] , [40] ]. 3.4.

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