29 The results of this trial confirmed a highly significant effect of brigatinib in improving PFS in comparison with crizotinib (median PFS 24.0 vs 11.0 months, respectively). 30 Alectinib The second generation ALK TKI alectinib was explored in comparison of other ALK inhibitors or of chemotherapy.
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Alk-rearranged lung adenocarcinoma: From molecular genetics to therapeutic targeting.
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