PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling.

The protein–protein interaction enrichment was highly significant ( p -values < 1.0 × 10 –16 ) for both #BiAll-93 and #MonoAll-2.13 (Supplementary Table 4a, b), and most of the proteins grouping together were linked to six distinct biological functions (Fig. 3 d–f). #BiAll-93 and #MonoAll-2.13 cells shared a cluster, representing the combination of four Gene Ontology (GO) terms that were associated to stress response, cell adhesion and proliferation, and processes of cellular and organismal development.

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