We found that compared with 5‐month‐old WT mice, APP/PS1 mice in the three age groups showed a decreasing trend in the percentage of time spent in the central area, although the difference did not reach significance (Figure S1D‐E ).
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Western blot analysis of autophagy‐related proteins (Figure 4D ) showed that LC3‐II expression exhibited an increasing trend in the hippocampus of APP/PS1 mice at 5 and 9 months of age and was significantly decreased at 13 months of age (Figure 4E ).