Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNα production.

Because transcription factor binding sites induced by stimulation with factors such as LPS have been reported to have lower signal intensity ( 20 ), we suspected that a weak GATA4 binding signal induced in the region approximately 3000 bp upstream of IFIT1B in U937 cells upon 2′3′-cGAMP stimulation might be significant ( Figure 5B ).

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