Analytical Characterization of Heterogeneities in mRNA-Lipid Nanoparticles Using Sucrose Density Gradient Ultracentrifugation.

For the lipid A parent formulations, A-DOPE showed a slight trend of higher particle size for F1 ( Figure 3 B), while the PDI increased from F1 to F3 (n.s., Figure 3 C) and EE% remained comparable across all fractions for both A-DOPE and A-DEPE LNPs ( Figure 3 D).

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