Similarly, a marginally significant negative correlation was found between early DNATG concentration and the average peripheral leukocyte, neutrophil, lymphocyte, and monocyte counts during follow-up ( r = -0.1806, P = 0.0280; r = -0.1473, P = 0.0740; r = -0.1419, P = 0.0850; r = -0.2392, P = 0.0034; respectively, Figure 2E - H ).
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Early proactive monitoring of DNA-thioguanine in patients with Crohn's disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers.
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