highly significantp -value < 2 × 10 − 16
The linear model is highly significant ( p -value < 2 × 10 − 16 ), and 62% of the ENL variance is explained by the time of development ( R a d j 2 ≈ 0.62 ), while the residuals of the model follows a normal distribution ( p -value 0.3375 in the Shapiro–Wilk test; see Supplementary SI.2 for details).