Potential Drug-Nutrient Interactions of 45 Vitamins, Minerals, Trace Elements, and Associated Dietary Compounds with Acetylsalicylic Acid and Warfarin-A Review of the Literature.

To harvest this cumulative mechanism and potentiate ASA, the concomitant use of tocopherols and tocotrienols was studied in a double-blind, randomized study on 100 patients (52 patients on ASA + vitamin E, 48 on ASA only) with transient ischemic attacks, minor strokes, or residual ischemic neurologic deficits, with highly significant reduction in platelet adhesiveness (2.7 × 10 5 platelets adherent/cm 2 for ASA + E–4.4 × 10 5 platelets adherent/cm 2 for ASA only) and significant reduction in the incidence of ischemic events in patients in the vitamin E plus aspirin group compared to the aspirin only group (three fatal events in ASA + E–6 in ASA only, one recurrent ischemic attack in ASA + E, two in ASA only, p < 0.05), with no significant difference in the incidence of hemorrhagic stroke between groups (three in both groups over 2 year period) ( Table 1 ) [ 213 ].

also in 132,142 other papers