Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition.

A highly significant interaction between PD and GT for both Rbp6 and Aldh1a2 ( p < 0.001) resulted in variance across PDs only in DKO ( p < 0.001) but not WT male mice, with significant upregulation in DKO male mice at PD35, PD40, PD45 ( p < 0.001) (Fig. 4b and Supplementary Table 2 ).

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