Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson's disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls.

Subject scores of the asymptomatic LRRK2 pathogenic variant carriers along this canonical variate revealed an increasing trend as a function of age from negative (HCs) towards positive subject scores (PD subjects) and were significantly different from HCs (DTBZ: p < 0.0001, MP: p = 0.002) and PD subjects scores (both tracers p < 0.0001).

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2 d, p = 0.03) and a borderline significant correlation for MP (p = 0.05).

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5 a), consistent with previous findings, with highly significant loadings for the first canonical variate, underlying the strong impact of the overall loss of dopaminergic terminals.

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