Among them, the upregulation of miR-197 and miR-144 in TB compared to HC was found to be highly significant with better diagnostic ability. miR-197-3p is a neutrophil associated miRNA which inhibits the protective cytokine, IL-22 and their downregulation increases the chance of protection to TB [ 40 ].
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A systematic review and meta-analysis of circulating serum and plasma microRNAs in TB diagnosis.
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