Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels.

Meanwhile, circulating IL-1β levels exerted an increasing trend in pAF and psAF patients (Fig. 1 F).

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The expression of leukocyte GPR43 mRNA in patients with paroxysmal AF (pAF) and persistent AF (psAF) represented a decreasing trend, while NLRP3 was gradually increased (Fig. 1 B, D).

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