Reply to: Population genetic considerations regarding the interpretation of within-patient SARS-CoV-2 polymorphism data.

Nat Commun · 2024 · PMC11021549 · PMID 38627383

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hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantP ≤ 5.0 × 10 −7actually significant

Purifying selection is highly significant for all models ( P ≤ 5.0 × 10 −7 , Z-tests) (Supplementary Fig. 1 ).

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