An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.

There was a decreasing trend of the hazard ratio (HR) with age, ranking from 2.35 (1.99–2.78) in 40–55 to 1.84 (1.72–1.96) in 70–82 years old group [ I 2 = 63%, P for heterogeneity ( P het ) = 0.027; Additional file 1 : Fig.

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