Bioinformatics analysis of the potentially functional circRNA-miRNA-mRNA network in breast cancer.

2.3 Selection criteria for filtered candidate miRNAs and mRNAs The selected miRNAs and mRNAs should have a strong association with both BC and other cancers in the literature (keywords such as "gene name, miRNA name, cancer, breast cancer, breast" were searched in the PubMed database), A distinct altered expression level of these mRNAs should be detected across all of the PAM50 subgroups from normal-like to the BLBC with an increasing trend in the form of a pan flute.

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BLBC has the greatest Log2FC values for 13 out of 18 DEGs (almost all target genes of miR-486-5p and miR-183-5p ) and the bar charts represents almost like a pan flute form, with the Log2FC values represent a decreasing trend from BLBC towards HER2, LumB, LumA, and Normal-like subtype.

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