Consistently, a pronounced decrease in the level of p62 was evident in FBW7 −/− cells compared to FBW7 +/+ cells, whereas there was an increasing trend observed in the LC3-II form ( Fig. 5 C ).
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The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1.
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