Testing a candidate composite serum protein marker of skin severity in systemic sclerosis.

Serum TNC concentration demonstrated a weak trend toward decreased serum concentration with disease duration in all cohorts ( r = 0.03, P = 0.32; r = 0.05, P = 0.17; r = 0.04, P = 0.28).

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The relatively small number of cases in each cohort is a major limitation and may explain why only trends of association were observed for some of the proteins that had been highly significant by Olink assay in the derivation BIOPSY cohort.

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