Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis.

Also, when autophagic degradation was inhibited by protease inhibitors E-64d and pepstatin, a nonsignificant trend of higher LC3-II accumulation was observed in WT compared to NFKB1 R157∗/R157∗ THP-1 monocytes ( Figure 5 E), suggesting its higher degradation.

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