Listeria-vectored cervical cancer vaccine candidate strains reduce MDSCs via the JAK-STAT signaling pathway.

With tumor progression, the proportions of cells exerting antitumor immune responses, including CD8 + T cells ( P < 0.001), NK cells ( P < 0.001), and M1-type macrophages ( P < 0.05), were significantly reduced at 28 days compared with mice at 0 day or 7 days, while the proportion of MDSCs, which promoted tumor progression, was significantly increased ( P < 0.05), and Treg also showed an increasing trend ( P > 0.05) (Fig. 2 A–G).

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2 H–L), the proportion of MDSCs was significantly lower ( P < 0.05), and the proportion of Treg showed a decreasing trend (Fig. 2 M, N).

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