Entorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease.

Decomposing PI impairments In contrast to the third “no distal cues” condition, performance differences between baseline and “no optic flow” conditions (return condition two) were borderline significant for hereditary but not physiological risk factors (two‐way FH x APOE ε4 F 1,77 = 4.42, P = 0.039; post hoc pairwise tests all P Tukey > 0.138; Figure 1E ), indicating that the PI impairment observed across all AD risk groups related specifically to orientation cue removal.

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