FACS analysis of PDAC tumors harvested at an early timepoint in treatment—day 10—when differences between treatments on tumor growth were not yet significant, revealed EGFRxEGFR, HER2xHER2, and EGFRxHER2 T-BsAb treatments increased the presence of TILs, which exhibited a highly activated phenotype denoted by high expression of effector cytokines.
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Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma.
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