Influence of maternal folate depletion on Art3 DNA methylation in the murine adult brain; potential consequences for brain and neurocognitive health.

2 , asymptotic P = .028 or exact P = .030 assessed), while CpGs 1, 2, and 4 were all on the borderline of significance ( Fig. 2 , asymptotic P = .045 or exact P = .052).

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While previously we reported increased methylation in both fetal and adult liver in response to low maternal folate across all genes assessed, in the brain we observed statistically significant hypermethylation at a single CpG within the Rsp16 gene promoter, and mean hypomethylation across all four CpGs measured within the Art3 gene promoter in response to maternal folate depletion, which was statistically significant also at one of these CpGs and of borderline significance at the other three.

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