Conversely, the reverse reaction for off-target effects may be thermodynamically favored, but if the kinetics of dissociation are slow, then the off-target effects may be significant since there may be a long-residence time of the inhibitor and the off-target enzyme, which leads to no functional difference between reversible inhibition and irreversible inhibition on the time scale of cellular stress response.
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Reversible Covalent Inhibition─Desired Covalent Adduct Formation by Mass Action.
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