Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.

While there was an increasing trend in the odds of lithium treatment response across the deciles, the most significant prediction contrast was found at the ‘extremes’ (1 st and 10 th decile) which comprised of ~20% of the total cohort (Fig. 2 ).

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