Dexamethasone in anesthesia practice: A narrative review.

Administration of dexamethasone 60 minutes or more prior to incision may be significant to decrease pain and inflammation.[ 14 ] Early administration of dexamethasone resulted in better postoperative pain relief and also decreased demand for analgesic in different studies.[ 15 , 16 ] Drug, if administered, just before the incision does not suppress inflammatory mediators.

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The trial concluded that dexamethasone given as a single dose of 8 mg intravenously led to highly significant decrease in PONV.

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