An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European population.

Hum Genet · 2024 · PMC11043142 · PMID 38519595

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may be significantno p-value reported

Furthermore, the relative expression of OTOG is higher in the apex than at the base of the cochlea, which may be significant given that hearing loss in MD patients is initially observed at low and medium frequencies (El-Amraoui et al. 2001 ).

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