Emergence of two distinct spatial folds in a pair of plant virus proteins encoded by nested genes.

The second positions of p22 , which are the third positions in p19 , have the frequencies of nucleotides U elevated by more than 30% compared to the base frequency of U across the rest of the genome, and reduced frequencies of the other three bases; in this case, the difference is highly significant, with p -value less than 10 −10 .

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