Acetyl-CoA is a terminal metabolite in this pathway, as in the fatty acid degradation pathway, but valine, leucine, and isoleucine show a decreasing trend in Tg/Tg, indicating that degradation is progressing ( Fig 5C ).
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iMPAQT reveals that adequate mitohormesis from TFAM overexpression leads to life extension in mice.
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As metabolites involved in fatty acid degradation, we also analyzed acylcarnitines, which are converted to acyl-CoA upon passage through the mitochondrial inner membrane, and observed an increasing trend in Tg/Tg ( Fig S4 ).